To all our customers, Here at Majestic Beauty made in Japan beauty products, we are committed to providing you with the best Japanese skin care products and services of the highest quality. Our sincere aim is to live up to our customers’ expectations in full and to bring them happiness and good fortune through our products.
With the most Japanese cosmetic products, it takes three months or more to see any changes in your skin. Our newly developed beauty serum gives you clear results in just 14 days!
The skin’s turnover time (renewal period) is typically 28 days. Cells take 14 days to move up from the skin’s basal layer to the granular layer; they then take another 14 days to form keratinocytes, and finally flake off. New cells are continually formed over this 14 day period, and then pushed up from the basal layer.
Stratum corneum (horny layer)
Stratum granulosum (granular layer)
Stratum Spinosum (spinous layer)
Stratum basale (basal layer)
Majestic Skin made in Japan beauty products encourages natural and healthy skin turnover, ensuring new cells form continuously over the 14-day period.
*The process of skin renewal and regeneration is called skin “turnover”. Cells are formed in the basal layer, and change shape as they move up to the surface. The cells become corneocytes (without nuclei) and die. These cells are pushed to the surface by newer cells. Eventually they naturally redden and flake off.
*Active product ingredient: Human stem cell conditioned culture fluid extract
Contains protein ingredients secreted when stem cells extracted from human fat are cultured. Subject to rigorous blood and DNA testing before use. Human adipose stem cell culture fluid is reported to contain over 150 growth factor protein ingredients derived from stem cells, including VEGF (Vascular endothelial growth factor), TGF (Transforming growth factor), FGF (Fibroblast growth factor), IGF (Insulin-like growth factor). These promote activity in the epidermal cells which produce skin, and in the fibroblasts which produce collagen, elastin and hyaluronan. They are self-regenerating.
Cells decline with age and metabolism slows down
Growth factors promote regular skin turnover
Old skin turns red and flakes off
Cells divide and move towards the skin’s outer layer
New cells are formed
Declining levels of collagen, elastin and hyaluronan
Encouraging collagen, elastin and hyaluronan
Human stem cell culture fluid extract
ADSC-CM is produced through secretion. It is rich in physiologically active substances such as cytokines, enzymes, and ECM constituent proteins. It has a range of uses as an activating ingredient, rejuvenating cells where activity has declined due to aging. ADSCM-CM promotes the biosynthesis of collagen and hyaluronan; smooths skin and protects against wrinkles; whitens the skin; stimulates production of fibroblasts, stem cells and epidermal cells; promotes hair growth; and has a range of anti-aging properties.
ADSC-CM is a protein ingredient secreted from cultured adipose stem cells extracted from human fat. Adipose stem cells are a type of fully-grown stem cell. They are easier to extract than bone marrow stem cells or umbilical cord blood cells, and, because of their abundance, have been increasingly used in anti-aging treatments and beauty products. Human adipose stem cell culture fluid is reported to contain over 150 growth factor protein ingredients derived from stem cells, including VEGF (Vascular endothelial growth factor), TGF (Transforming growth factor), FGF (Fibroblast growth factor), IGF (Insulin-like growth factor). ADSCM-CM is highly functional substance that prevents skin aging and damage, and promotes the regeneration of hyaluronan, collagen and elastin which are essential components of skin tissue. Stem cell culture fluid is recognized to have a range of uses, including for anti-aging treatments and the promotion of tissue regeneration.
The substances secreted by stem cells are rich in physiologically active ingredients and proteins needed for tissue regeneration. Physiologically active cytokines play a key role in activating cells through combining with cell receptors. Also, extracellular proteins such as hyaluronan, collagen and elastin help the process of tissue formation.
ADSC-CM is absorbed directly by stem cells, fibroblasts and epidermal stem cells. It promotes cell activation and cell reproduction, and accelerates the skin tissue regeneration process.
The graph in Diagram 1 shows hyaluronan generation by ADSC-CM. The lines on the graph show the amount of fibroblast hyaloronan produced in order, starting with the negative control group from the bottom (untreated test group); then the positive control group (treated with TGF-ß1: growth factor stimulating hyaluronan production); then ADSC-CM over a period of 12/24/36/48 hours. In this test ADSC-CM is observed to induce a larger volume of hyaluronan expression than the positive test control group using a hyaluronan growth factor.
This graph shows the results of the fibroblast proliferation acceleration test. ADSC-CM was applied to fibroblast cells for a 48-hour period, and the cell proliferation rates were placed in order, with the promotion of cell proliferation observed according to concentration
Fibroblast cells are the source of collagen,elastin and hyaluronan, which are vital for skin tension and elasticity.
When the fibroblast cells are active, collagen, elastin and hyaluronan ensure our skin’s metabolism is working smoothly, and keep our skin firm and supple.
However, when fibroblast cells decline and stop working due to damage from aging or ultraviolet rays, the skin’s metabolism slows down. Declines in collagen and elastin through skin degeneration means the skin loses elasticity, and declines in hyaluronan lead to a reduction in the skin’s moisture levels. As a result, subcutaneous tissue becomes loose.